Replays 9èmes Journées de la Recherche sur la SLA et les MNM

Les 9èmes Journées de la Recherche SLA/MNM se sont déroulées les 11 et 12 octobre 2023 à l’ICM à Paris : découvrez les replays !

FILSLAN « training through research » project award 2022

• Unconventional secretion of TDP-43 free aggregates by the ubiquitin-specific protease 19 (USP19), Flavien PICARD – Vidéo non disponible

Session 1: Pathophysiology of motor neurone diseases

• Conference : Glial cells at the neuromuscular junction : a new therapeutic target in ALS, Richard ROBITAILLE – Vidéo non disponible
• Deciphering the role of TBK1 in mouse motor neurons and microglial cells, and its implications for ALS/FTD pathogenesis, Isadora LENOEL – Vidéo non disponible
• Specific role of neuronal versus microglial P2X4 receptor in ALS pathogenesis and its potential use as a biomarker, Sara CARRACEDO – Voir la vidéo
• Lateral hypothalamus-dependent impairment in ALS, Simon J. GUILLOT – Voir la vidéo
• Engineered TDP43 condensates with controlled assembly/disassembly as model for studying ALS pathological aggregates in human cells, Pauline COMBE – Vidéo non disponible
• Cortical sensorimotor integration in patients with ALS, Véronique MARCHAND-PAUVERT – Voir la vidéo
• Better Diagnosing and Understanding C9orf72 Repeat Instability in C9orf72-ALS Blood and Brain, Georg HAASE – Vidéo non disponible
• One-carbon metabolism contribution to development and degeneration in ALS, Marina HERNAN-GODOY – Vidéo non disponible

Session 2: Biomarkers and therapies in motor neurone

• Conference: New treatments for ALS in 2023, Gaëlle BRUNETEAU – Vidéo non disponible
• Characterization of a therapeutic approach to deliver scFv targeting TDP-43 pathology in ALS, Yara AL OJAIMI – Voir la vidéo
• Validation of exportin-1 (XPO-1) and mitogen-activated protein kinase kinase 2 (MAP2K2) as molecular drug targets in amyotrophic lateral sclerosis, Mojan PARVAZ – Voir la vidéo
• Therapeutic administration of the borna virus x protein by a viral vector AAV10 in a mouse model of ALS, Jeflie TOURNEZY – Voir la vidéo
• A better 1-year survival prognosis estimation model for amyotrophic lateral sclerosis using UMAP and regression ridge, Thibault ANANI – Voir la vidéo
• Quantitative brainstem in amyotrophic lateral sclerosis: implications for predicting non-invasive ventilation needs, Mohammed KHAMAYSA – Voir la vidéo
• Multimodal automated prediction from quantitative MRI for patient classification and stratification, Matthieu GILSON – Voir la vidéo
• Implication of central nervous system barrier impairment in amyotrophic lateral sclerosis: gender-related difference in patients, Hugo ALARCAN – Voir la vidéo

ARSLA session

• Relationship between diaphragm weakness, taste and smell and food intake in ALS, Marjolaine GEORGES – Voir la vidéo
• Corneal Trigeminopathy and Amyotrophic Lateral Sclerosis: Myth or Reality?, Raoul Kanav KHANNA – Voir la vidéo
• Transactive response DNA-binding protein 43 is enriched at the centrosome in human cells, Philippe CODRON – Voir la vidéo
• Evaluation of the potential of isoprostanoids to predict ALS progression, Claire VIGOR – Voir la vidéo
• Development of a biomarker panel for ALS: tracking treatment efficacy in a SOD1 murine model, Stephanie DUGUEZ, Frederique RENE – Vidéo non disponible
• Detection of Peripherin and misfolded SOD1 as novel biomarkers in ALS, Sylvain LEHMANN- Voir la vidéo

Session 3: Molecular mechanisms of motor neurone diseases

• Conference: Cryptic splicing: from foe to friend in tackling amyotrophic lateral sclerosis, Pietro FRATTA – Vidéo non disponible
• The maxomod project: multiomic ALS signatures highlight sex differences, molecular subclusters and the MAPK pathway as therapeutic target, Laura TZEPLAEFF – Voir la vidéo
• Identifying motor neuron specific alterations in fus deletion mutant zebrafish model of ALS, Xhuljana MINGAJ – Voir la vidéo
• Disrupted spontaneous neural activity in the embryonic SOD1G93A mouse model of amyotrophic lateral sclerosis, Ullas KANNANTHA – Voir la vidéo
• Investigating variants in NUP50 as risk factors for amyotrophic lateral sclerosis, Olga ROMAN – Voir la vidéo
• TBK1 mutant zebrafish show increased programmed cell death and dysregulation of critical pathways involved in amyotrophic lateral sclerosis (ALS), Quentin RAAS – Voir la vidéo
• Heterozygous SPTLC1 p.Leu39del is a major cause of slow-progressing juvenile ALS, Claire GUISSART – Voir la vidéo

Conference

• Mitophagy failure in alzheimer’s disease: a hope for a diagnostic application and therapeutic targeting, Mounia CHAMI – Vidéo non disponible

Round table

• RT1 – Modeling and predicting the progression of neurodegenerative diseases: application to clinical trial design, Stanley DURRLEMAN – Voir la vidéo
• RT2 – Harnessing Big Data, Omics, and AI, Ahmad AL KHLEIFAT – Vidéo non disponible
• RT3 – Machine-learning based on neuroimaging patterns: opportunities and challenges, Peter BEDE – Vidéo non disponible