Les 10èmes Journées de la Recherche SLA/MNM se sont déroulées les 9 et 10 octobre 2024 à l’ICM à Paris : découvrez les replays !
Replays 10èmes Journées de la Recherche sur la SLA et les MNM
Session 1: Pathophysiology of Motor Neurone Diseases
- Conference : Physiological and multi-omic signatures of cortical impairment in ALS, Caroline ROUAUX – Vidéo non disponible
- Metabolic modification in cellular and animal models of FUS-ALS, Xhuljana MINGAJ – Vidéo non disponible
- Impairment of hypothalamic MCH neuronal network precedes disease onset and MCH degeneration in ALS mouse model, Jelena SCEKIC-ZAHIROVIC – Vidéo non disponible
- Characterization of blood-derived macrophages of Amyotrophic Lateral Sclerosis (ALS) for therapeutic and diagnostic approach, Matthieu RIBON – Vidéo non disponible
- Deciphering the crosstalk between motor neurons and microglia in Amyotrophic Lateral Sclerosis with human spinal cord organoids, Killian GHIKH-MIMIETTE – Vidéo non disponible
- Unconventional secretion of misfolded SOD1 in ALS: a novel mechanism of toxicity spreading, Philippe GOSSET – Vidéo non disponible
- Contribution of neutrophils extracellular DNA traps to Amyotrophic Lateral Sclerosis pathogenesis, Caroline RITACCO – Vidéo non disponible
FILSLAN « Training through research » project award 2023
- Study of the pathogenicity of the TDP-43 protein in the neurodegenerative impairment of sporadic Amyotrophic Lateral Sclerosis, Alexia BODIN – Vidéo non disponible
- Epistemic challenges of amyotrophic lateral sclerosis (ALS), Anne FENOY – Vidéo non disponible
- Therapeutic effects of the borna virus x protein in SOD1G93A mice, Jeflie TOURNEZY – Vidéo non disponible
Session 2: Biomarkers and therapies in Motor Neurone Diseases
- Conference: Antisense oligonucleotide therapies for ALS, Philip VAN DAMME – Voir la vidéo
- Identification of proteomic clusters in the CSF of sporadic ALS patients, Laura TZEPLAEFF – Vidéo non disponible
- Sigma-1 receptor activation as a strategy to counteract ALS pathology, Hugo MOURIER – Voir la vidéo
- Longitudinal MRI Study Reveals Potential Neurodevelopmental Disorders in C9Orf72 Mutation Carriers, Giorgia QUERIN – Vidéo non disponible
- Brainstem as a proxy for respiratory and bulbar function in Amyotrophic Lateral Sclerosis, Mohammed KHAMAYSA – Voir la vidéo
- Characterization of a therapeutic approach to deliver scFv targeting TDP-43 pathology in ALS, Samira OSMA – Voir la vidéo
- Care pathway heterogeneity in Amyotrophic Lateral Sclerosis: effects of sex, age class and onset-site related symptoms, Marc DIBLING – Vidéo non disponible
ARSLA session
- Elucidating the role of the spinal sympathetic autonomous neurons in ALS, Maëlle OLLIVIER – Voir la vidéo
- Unravelling the genetic contribution to prognosis and endophenotypes in ALS using an extended cohort of patients (PULSE-WGS), Luc DUPUIS – Voir la vidéo
- Functionnal analysis of genetic variants of unknown significance in SOD1 gene in Amyotrophic Lateral Sclerosis, Léa BEDJA—IACONA – Vidéo non disponible
- Involvement of NUP50 in Amyotrophic Lateral Sclerosis, Chantal SELLIER – Voir la vidéo
- SOD1G93A neurotoxicity initiated by subversion of cellular prion protein signaling in Amyotrophic Lateral Sclerosis, Benoit SCHNEIDER – Vidéo non disponible
- Anxa2 mRNA, missing its SMN partner, shows early defects of axonal localization in SMA motoneurons, Pauline DUC – Vidéo non disponible
Session 3: Molecular mechanisms of Motor Neurone Diseases
- Conference: Understanding the life cycle of TDP-43: aggregation triggers & toxicity effectors, Magdalini POLYMENIDOU – Vidéo non disponible
- Propagation and toxicity of superoxide dismutase in Amyotrophic Lateral Sclerosis using human iPSC-derived motor neurons, Coline JOST MOUSSEAU – Voir la vidéo
- Nifuroxazide rescues the deleterious effects associated with micos instability in disease models, Loan VAILLANT-BEUCHOT – Voir la vidéo
- Automated analysis of iPSC-derived motor neurons from TARDBP ALS patients reveals altered neuronal net organization and subcellular TDP43 localization, Elena PASHO – Voir la vidéo
- Towards Understanding C9orf72 Repeat Instability in ALS/FTD, David GENTIEN – Vidéo non disponible
- Beneficial effect of the environmental enrichment on a transgenic mouse model of FTD-ALS (FUSΔNLS+/-), Anaelle BURGARD – Vidéo non disponible
- Role of FUS in Nucleolar Homeostasis, Jianbo HUANG – Vidéo non disponible
Conference
- Unlocking the Secrets of Minipuberty and GnRH Neurons: From Brain Development to Cognitive Resilience and Beyond, Vincent PREVOT – Voir la vidéo
Round table: What did we learn from recent failures in therapeutic trials in ALS?
- Recent failures in ALS therapeutic trials, from a clinician’s perspective: the challenge of clinical heterogeneity, Gaelle BRUNETEAU – Voir la vidéo
- Learning from failed trials in the past and proposals for the future, Thomas MEYER – Voir la vidéo
- Statistical learnings from recent therapeutic trials in ALS, Ruben VAN EIJK – Voir la vidéo
- Round table, Gaelle BRUNETEAU, Thomas MEYER and Ruben VAN EIJK – Voir la vidéo
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